ABSTRACT
Background: There is little evidence about antioxidant properties of vitamin D. Recent studies suggest that oxidative stress may play a major role in the pathophysiology of polycystic ovary syndrome [PCOS], but the association of vitamin D with oxidative stress is still not known in PCOS
Objective: The goal of the present study was to evaluate the correlation between serum 25-hydroxy vitamin D and oxidative stress markers in PCOS group compared to control group
Materials and Methods: 60 PCOS women [20-40 yr old] and 90 healthy women as control group were participated in this case-control study. Fasting serum level of 25-hydroxy vitamin D 25[OH] D, glucose, insulin, calcium, malondialdehyde [MDA], protein carbonyl [PC], also homeostasis model assessment for insulin resistance [HOMA-IR] and fasting glucose to insulin ratio [FGIR] were measured
Results: It was found that the mean of serum 25[OH]D was lower in the PCOS group [10.76+/-4.17] than in the control group [12.07+/-6.26] but this difference was not statistically significant [p=0.125]. Fasting insulin, HOMA-IR and MDA were significantly higher in the PCOS patients as compared to the controls, whereas PC level did not differ for the two groups [p=0.156]. No significant correlations were found between 25[OH] D levels and oxidative stress markers [MDA and PC]
Conclusion: The findings indicated no significant differences in the serum 25[OH] D levels between the PCOS patients and the matched controls. Also, no correlation was found between the serum vitamin D levels and oxidative stress markers in both groups